Barbiturates.
نویسنده
چکیده
منابع مشابه
SYNTHESIS OF NEW PHASE- 1 METABOLITES OF TWO BARBITURATES
The new 4'- hydroxy and 3'- aldehyde phase- 1 metabolites of butobarbitone and pentobarbitone are fully synthesized for the first time. These metabolites were used to idenfity and quantify the natural metabolites in human urine after single and multiple doses of these drugs. The synthesized metobolites have spectral characterizations (IR, NMR, U.V. and mass spectroscopy) consisted with the ...
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A recently developed procedure for alkylatiori of organic acids has proven extremely successful for preparation of volatile alkyl derivatives of the barbiturates for gas-chromatographic analysis. Soluble salts are formed in a mixture of N,N-dimethylacetamide and methanol. These in turn react rapidly with alkyl iodides to form the corresponding alkyl derivatives. The butyl derivatives of barbitu...
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A gas-chromatographic method is described for the quantitative deter. mination of 11 barbiturates and glutethimide in blood. The extracted barbiturates are methylated and injected into a 7% DC-200 column. Use of methohexital as the internal standard, as well as the addition of standards to a drug-free sample of blood, compensates for losses and for differences in the distribution coefficient of...
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Despite the widespread use of barbiturates and their clear potential for abuse, little is known of their neurochemical mechanisms of action. Our purpose is to review the neurochemical effects of acute and chronic barbiturate administration, with particular emphasis on the relationship between neurochemical changes and the development of tolerance and dependence. The electrophysiological effects...
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The effects of ten narcotic analgesics and three barbiturates have been investigated on respiratory rate, respiratory minute volume and blood Pco3 in the unanaesthetized rabbit. Both groups of drugs produced respiratory depression, and whilst the pattern of depression was similar for drugs of the same group, there were three main differences in the pattern of depression between the narcotic ana...
متن کاملSimultaneous Determination of Barbiturates and Salicylates by Ultraviolet Spectrophotometry.
A rapid method based on UV spectrophotometry is described for simultaneous determination of salicylates and barbiturates in serum. While barbiturates have no absorbance above 280 m and extracted normal serum has insignificant absorbance, salicylate has a maximal absorbance peak at 296 mjh, which is proportional to concentration. The barbiturate concentration can be calculated from absorbance di...
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عنوان ژورنال:
- The Mount Sinai journal of medicine, New York
دوره 50 4 شماره
صفحات -
تاریخ انتشار 1983